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The phrase "a big challenge is" is correct and usable in written English.
You can use it when introducing a significant difficulty or obstacle in a discussion or analysis.
Example: "A big challenge is adapting to the rapid changes in technology that affect our industry."
Alternatives: "a major obstacle is" or "a significant difficulty is".
Exact(29)
A big challenge is that ovarian cancer is very rare.
A big challenge is accessibility to basically everywhere.
A big challenge is the discrimination of sulfhydryl-containing amino acids due to their structural similarity.
A big challenge is getting the cost of their battery capacity below $400 per kilowatt-hour.
"A big challenge is getting people to talk across their disciplines," says Martin.
Today, a big challenge is how to create customers in the era of the internet.
Similar(30)
Battelle: I was going to ask if a big challenge was looming government regulation of online advertising.
It's a big challenge being a spiritual teacher in a secular culture.
MARILYN: A big challenge was that originally our script was structured to be a big budget studio movie.
Often a bigger challenge is bureaucratic: getting proper government permits.
A bigger challenge is when the scientists aren't sure what they are looking for.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com