The phrase "a big challenge at" is correct and usable in written English.
It can be used when discussing a significant difficulty or obstacle related to a specific situation, location, or organization.
Example: "The project presented a big challenge at the initial stages due to limited resources."
Alternatives: "a major hurdle in" or "a significant difficulty with".
Shennan also has a big challenge at 6Music, which has only been a moderate success at best.
He spoke with Brad Spurgeon of the International Herald Tribune. A. It was a big challenge at first, especially with me coming from a style of racing where there was a small structure.
"The marketing was a big challenge at the beginning until I understood it," she says.
Coming from 5,000 square feet to 500 was a big challenge at first but it led to me exploring the digital world more as I had been only focused on creating physical art over the last few years.
It's going to be a very big challenge at a place like Time Inc. with so many different, powerful constituencies".
That's a big challenge, and today at TechCrunch Disrupt NY, we are annoucing one key initiative to get us there: the CrunchBase Venture Program.
They've got a lot of strengths, notably up front in the scrum and their maul, and when they bring big runners round the corner they're very dangerous, so it's going to be a big challenge for us out at Kilmarnock".
Chris Butcher commented, "For Halo 2 we had our sights set very high on networking.... Going from having no Internet multiplayer to developing a completely new online model was a big challenge to tackle all at once, and as a result we had to leave a lot of things undone in order to meet the ship date commitment that we made to our fans".
This is a big challenge to current efforts at addressing HIV/AIDS pandemic in Nigeria and public health education campaigns.
Analysis of precisely controlled post-translational modifications of proteins, often with addition of only a small functionality (e.g., single phosphorylation), which can change activity of a kinase up to 10 times, is a big challenge for analytical chemistry at present.
