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"It simply says that this must be done according to a different procedure, with a better framed question and a better substantiated decision".
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We feel that this new version has substantially gained in clarity and that our conclusions are now even better substantiated.
Cleomenes' offer of some kind of new deal to the Arcadians (better substantiated than his dealings with the helots) came to nothing with his spectacular death; he went insane (it was alleged), was imprisoned, and committed suicide.
Nonetheless, current knowledge about TMPRSS4 processing needs to be better substantiated.
Whilst the technical details are more revealing and the claims better substantiated in this current revision, the clarity of the manuscript has, in our view, not improved.
B) The claim that the PIP2-Dia interaction is mediated by direct binding through the BD domain would be better substantiated by lipid flotation assays showing that the BD domain binds PIP2 and that the introduced point mutations abrogate binding.
Author's response : We find that, since the alignment does not indicate a high degree of amino acid sequence similarity in the P domain of the CP proteins, a structural assessment is warranted to better substantiate claims of interviral transfer and homology of the BSL and S-P-type CPs of tombusviruses.
The film's producers say they chose Smith precisely because of his reservations about the clandestine nature of Ollivier's involvement, to better substantiate its claims.
Next, in vivo metastasis assay was performed to better substantiate results from in vitro studies.
Additional data should be provided for the neuronal ablation section to better substantiate the claims.
An emerging field known as molecular epidemiology augments classical epidemiological approaches with exposure-associated molecular biomarkers to better substantiate causal links.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com