Suggestions(1)
Exact(3)
The similarity is due mainly to eight regions of ∼75 amino acids each resembling the B domain of Cna that form a beta sandwich extended stalk structure [72], [73].
Is this a beta sandwich?
This consensus sequence corresponds to the carbohydrate-recognition domain (CRD), which is a beta sandwich of about 135 amino acids long and is responsible for β-galactoside binding (2, 3, 19, 75).
Similar(57)
X-ray crystallographic studies revealed that the osmotin is composed of three domains of which domain I consists of 11 beta-strands, arranged in the shape of a beta-sandwich, domain II consists of several loops extending from domain I and stabilized by four disulfide bonds and domain III consists of a small loop with two disulfide bonds (Figure S5) [5].
Solved structures of C2 domains reveal a beta-sandwich fold consisting of eight antiparallel beta-strands connected by highly variable surface loops [ 16].
It is reported that FHA domain is 80-100 aainoacid (aa) long folded into a 11-stranded beta sandwich, which sometimes contains small helical insertions between the loops connecting the strands.
The structure was shown to be a nine-strand beta sandwich with previously unappreciated similarity to the receptor-binding domains of several other toxins of spore-forming bacteria, giving strong evidence for the presence of a common ancestor for several receptor-binding domains of bacterial toxins (Van Itallie et al. 2007).
The FHA domain is a phosphopeptide recognition motif spanning 80 to 100 amino acid residues folded in an 11-stranded beta sandwich which recognizes phosphopeptide [21], [22].
The adiponectin monomer (shown in Figure 2A) present 11 beta-strands organized in an architecture of "mainly beta sandwich" type.
Nonetheless, it may be worthy of mention that the lipocalin and C2 domains share a lipid-binding function, as well as an eight-stranded anti-parallel beta sandwich structure [ 46, 47].
On the other side of the beta sandwich (Figure 5C), residues Lys244, Arg245 and Gln247 of IL-3R alpha are also involved in beta subunit binding.
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