Five drug classes (and ATC numbers) were recorded, including agents acting on the rennin-angiotensin system (C09), called Group A hereafter; beta blocking agents (C07), called Group B hereafter; calcium channel blockers (C08), called Group C hereafter; diuretics (C03), called Group D hereafter; and antihypertensives (C02), called Group O hereafter.
Patients at risk for the development of diabetes, who are identified with the PreDisc-Score should preferably be treated first line with ramipril rather than a diuretic or beta blocking agent for arterial hypertension.
The following drug-classes (and ATC-numbers) were included: alpha blocking agents (C02C A), thiazides (C03A, C03B og C03E), beta blocking agents (C07), calcium channel blockers (C08), ACE-inhibitors (C09A), ACE-inhibitors combined with a diuretic (C09B), angiotensin II antagonists (C09C), and angiotensin II antagonists combined with a diuretic (C09D).
Like the subjects, she was also a healthy female who was not taking beta blocking medications or any other medications affecting respiratory or heart rate.
In addition, it has accurately underlined drugs known structural similarities, such as the beta-adrenergic agonist dobutamine reclassified from cardiac therapy to beta blocking agents, and the antihelmintic ivermectin reclassified as an antibacterial.
Finally, we were aware of the potential influence of antihypertensive medication (calcium blocking agents, beta blocking agents) that may alter sympathetic drive and thereby uptake of 123I mIBG.
At least one type of antihypertensive drug was taken by 85.4% of the patients (44.9% diuretics, 46.8% Beta blocking agents, 41.5% calcium antagonists, 51.2% inhibitors of the renin- angiotensin system, 9% central acting drugs).
▪ C07A: beta blocking agents.
Another explanation is the prescription of antihypertensive medication; beta blocking agents and diuretics increase the risk of incident diabetes [ 29].
The information on pharmaceutical treatment concerned the different drug groups advised: diuretics, ACE inhibitors or ARBs, beta blocking agents, aldosteron blocking agent, and digoxin.
Nearly all patients received optimal pharmacologic therapy: antiplatelet 100%, beta blocking 83,9%, ACE inhibitors 74,4%, and statins 91,2%; it was ordered according to their clinical status.
