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There was no evidence for a benefit of intervention immediately after the standard CST group programme on the family caregiver outcome measures.
Arguably, these features suggest a population where there may be a benefit of intervention and follow-up to prevent cardiovascular risk.
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This would destroy the trial's ability to identify a benefit of the intervention, if one exists.
In summary, a clearly defined and simplified prophylactic volume expansion strategy showing a benefit of earlier intervention in patients with markedly elevated urinary NGAL values, indicating CIN, might arise from the data this study produces.
A negative effect size indicates a benefit of the experimental intervention.
Although nearly two thirds of patients (n=661) reported improvement of symptoms as a benefit of percutaneous coronary intervention (site range 52-87%), only 1% (n=9) identified this as the only benefit.
A number of studies on preoperative interventions for populations of hip- and knee arthroplasty patients point to the same result, namely a benefit of initiating the intervention already prior to surgery [ 25, 26].
4 6 All but one of the nine randomised clinical trials to date of arthroscopic surgery in middle aged or older people with persistent knee pain failed to show an added benefit of interventions including arthroscopic surgery over a variety of control treatments.
4 5 6 All but one of the nine randomised clinical trials to date of arthroscopic surgery in middle aged or older people with persistent knee pain failed to show an added benefit of interventions including arthroscopic surgery over a variety of control treatments.
Others propose temporary suspension of the screening and treatment for GDM or elevating the cut-off threshold indicating a GDM diagnosis until a clear benefit of an intervention has been presented [ 25].
After removing some of the trials and data based on more rigorous standards for a high quality meta-analysis, a significant benefit of the intervention could no longer be shown.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com