The growing availability of drugs, diets (Orentreich et al., 1993), developmental interventions (Sun et al., 2009), and mutations (Brown-Borg et al., 1996; Ladiges et al., 2009) that extend mouse mean and maximal lifespan provides a battery of model systems in which to look for pathways that may be shared among these different anti-aging interventions.
A battery of computational models have been developed to address false-positives due to nonlinear amplification, false-negative allelic drop-out due to amplification bias, non-uniform coverage, and noise that arises during single-cell genome or transcript amplification (Table 2) [40].
On the contrary, stress counteraction has been shown as an effective therapeutic strategy against overnutrition-related glucose disorders in a battery of animal models.
Male and female 12 weeks-old R6/1 mice and their wild-type littermates were tested on a battery of tests modeling some of the major neuropsychiatric non-motor symptoms of HD: alterations in social interest, social interaction and communication, as well as disturbances in prepulse inhibition of the acoustic startle response (PPI) and circadian patterns of activity.
The multi-model scheme contains a battery of time-varying models which are updated using a modification rule.
An additional consideration is establishing the criteria for assembling a battery of alternative DNT models.
We then went on to assess the mutants in a battery of tests to model the psychotic, cognitive and negative aspects of schizophrenia and show that PNS influenced specific anxiety-related behaviour in all animals.
The Food and Drug Administration, alongside other interested agencies, has not yet given its regulatory imprimatur to organs-on-a-chip; they must first be validated against a battery of well-established animal models.
Despite the wide spread use of Urtica urens as an anxiolytic, there are no pharmacological data to support this, and therefore we undertook the study to evaluate the anxiolytic potential the methanolic extract of Urtica urens by using a battery of appropriate rodent test models.
This report describes the construction, optimization and validation of a battery of quantitative structure activity relationship (QSAR) models to predict reproductive and developmental (reprotox) hazards of untested chemicals.
