Sentence examples for a basis for selectivity from inspiring English sources

This provides a basis for selectivity which is desired against breast tumour cells.

In particular, the recombination test could serve as a basis for the selection and the study of inhibitory molecules as well as for the analysis of reaction selectivity using chimeric proteins.

In addition, the nonmodified AKB sequences inherently have specificity for either PKA-RI or PKA-RII, thereby providing a basis for PKA-R isoform selectivity.

This mode of interaction provides a basis for high affinity and selectivity of target gene recognition and allows for the differential action of TGF-β in different cell types [ 11].

Molecular modeling of the SH2 domains of Stat3 and Stat1 bound to compound revealed that compound interaction with the hydrophobic binding site was the basis for selectivity.

Sequence and structural analysis of the SH2 domains of Stat3 and Stat1 revealed that the ability of the compound to interact with the hydrophobic binding site was the basis for selectivity.

24 In the present study we developed dopamine D1 receptor models to better understand the molecular basis for selectivity between full agonists and structurally similar inactive compounds.

The latter inhibits hOGT in vitro (Ki=8 μM) and in vivo, although the basis for selectivity over other GlcNAc transferases remains to be fully explained [ 9].

To further understand the structural basis for selectivity, we determined the crystal structure of CpOGA in complex with GlcNAcstatin D. These data show that GlcNAcstatin D binds deep into the active site of CpOGA, with the sugar moiety adopting a E conformation, and assuming the same conformation as observed for the GlcNAcstatin C complex [ 41].

In this study, the basis for selectivity of CDV for HPV+ tumor cells could be demonstrated based on analysis of drug incorporation into genomic DNA as well as gene expression profiling in HPV+ tumor cells, HPV- immortalized keratinocytes and normal keratinocytes.

They also provide a basis for the design of kinase inhibitors with the desired selectivity profile.