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Knowing the MOA can reduce uncertainties in chemical risk assessments, providing, for example, a basis for extrapolating effects across species (Benson and Di Giulio 2007).
Unambiguous assignment of these substances to a particular risk category is often hindered by incomplete and inadequate data, making it necessary in many instances to use scientific judgment as a basis for extrapolating beyond the limited or nonexistent database.
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Although we lack an a priori basis for extrapolating our result to higher order, it is evident that the performance level of a method based on DRA is an easy benchmark to exceed.
Given the conserved role of GABAergic signaling, results of assays assessing impacts on this pathway are likely to be informative of potential effects across a similarly broad range of species and can provide a reasonable basis for extrapolating mammalian health data to other species.
A physical basis for extrapolating tokamak parameters from existing devices to reactor scale is summarised along with the engineering requirements for the functional systems of fusion devices.
This provides a more robust basis for extrapolating long-term outcomes than previous approaches [ 18, 19, 21].
To better understand the complex interactions of chemicals within a mixture, it is essential to develop a research strategy which provides the basis for extrapolating data from single chemicals to their behavior within the chemical mixture.
There remains no good basis for extrapolating findings between different pasture and rangeland systems.
Therefore, available data on parenteral GLN supplementation cannot be extrapolated to EN supplementation and thus may not be used as a basis for recommendations for enteral GLN administration.
The question "can the approach used for radiation protection standards, i.e., to extrapolate dose--response relationships to low doses, be applied to combustion pollutants?" provided a basis for discussion.
"There is a basis for this movement.
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