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The phrase "a basic difference between" is correct and usable in written English.
It can be used when discussing distinctions or contrasts between two or more subjects or concepts.
Example: "There is a basic difference between qualitative and quantitative research methods that researchers must understand."
Alternatives: "a fundamental distinction between" or "a key difference between".
Exact(23)
Likewise – with all due respect for the evolutionary insights developed in "Collective evolution and the genetic code" [ 190] – calling "Evolution of the genetic code, translation, and cellular organization itself" a "Lamarckian process" also appears misleading by the implied suggestion of a basic difference between dynamic modes operating at different stages of the emergence of life.
I think this is a basic difference between us.
They linked the disparity to a basic difference between Cuba and Haiti: one is Communist, the other simply impoverished.
The Google case underscores a basic difference between the approaches to monopoly power in Europe and the United States.
The crux of the problem is a tax break that was originally intended to compensate for a basic difference between American and European tax law.
A basic difference between Peirce and James is discernible in their respective conceptions of the direction to be taken by pragmatic analysis.
Similar(36)
A basic difference exists between aquatic non-vascular and land-living vascular plants; the latter exhibit a particular intriguing surface chemistry and architecture.
There was "a basic difference of philosophy between me and Mr. Nixon on occasion" about dealing with the press, he told The New York Times in 1974.
1199? or 1238 Udipi, India c. 1278 or 1317 Udipi, India Madhva, also called Anandatirtha or Purnaprajna (born c. 1199 or 1238 ce, near Udipi, Karnataka, India died c. 1278 or 1317, Udipi) Hindu philosopher, exponent of Dvaita ("Dualism"; belief in a basic difference in kind between God and individual souls).
But like you don't have to be a wine connoisseur to know the basic difference between a red and a white, you don't have to be an expert to get started on different tobaccos.
The basic difference between a contract for a house and one for a co-op apartment, Mr. Weinstein said, is that the former provides for the sale of real estate while the latter provides for the sale of stock in a corporation and the transfer of a proprietary lease for a particular apartment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com