Sentence examples for a basic defect from inspiring English sources

These results also furnish a compelling illustration of a basic defect of "traditional" (piecewise-linear/circular) G code path descriptions namely, the fundamental conflict between geometrical path accuracy (which entails use of many short G code segments) and the accurate and smooth maintenance of rapid commanded feedrates.

Recently, demonstration of subnormal insulin stimulation of ATP turnover rates in Type 2 diabetes has been postulated as a basic defect which limits glucose metabolism [ 5– 8].

We conclude that the most frequent EHF allele, designated as 10-14 in our marker combination EHFSat1-EHFSat2, wassociatedted with a CF-typical basic defect phenotype that is characterized by a high response to amiloride in NPD and by the absence of residual chloride secretion in ICM.

As the most frequent EHF haplotype was associated with a CF-typical basic defect phenotype, that is, high response to amiloride and the absence of CFTR-mediated residual function, we decided to define two subgroups, one of which carries two rare EHF alleles (seven patients) and one of which carries at least one frequent EHF allele (nine patients).

The specific effects on the proteome observed here can be attributed to the basic defect in NBS, defective DNA repair [14].

These findings suggest that CLCA4 modulates the capability to express residual chloride secretion in colonic tissue and therefore acts as a modifier of the basic defect in intestinal cells of CF patients.

The result of a genetic test describes the basic defect and excludes secondary effects; thus, it is more reliable for genetic counseling and for family planning.

However, new therapies modulating defective CFTR, the basic defect underlying CF, have started to hit the clinic and several others are in trial or in development.

This result shows that these mutants are able to move and that their defect is restricted to high quality food and is not linked to a basic locomotory defect.

The manifestation of the monogenic disease cystic fibrosis results from the cystic fibrosis transmembrane conductance regulator (CFTR -mediated basiCFTR -mediateded as an altered chloride transport.

An association study comparing F508del homozygous CF patient subsets selected for an extreme clinical phenotype and/or their basic defect manifestation tested the genes STAT3, IL1B, and IFNGR1 as modifiers of CF disease.