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A basal model including the clinical, pathological and biological variables (except gabarapl1) associated with prognosis was first built.
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For each pollutant, mortality outcome, and city, the exposure on the current day (lag 0) was introduced into the basal model as a smoothing term.
Because of its cGMP specificity, PDE5 is included in the basal model but plays only a minor role under basal conditions and is insignificant for cAMP regulation.
Chikumbo and Steward ([2007]) developed a basal area model using data from thirteen planted stands.
The idea of "islands" provides a "basal genetic model for understanding domestication that could be tested in other species," says Ludovic Antoine Alexandre Orlando, an evolutionary geneticist at the University of Copenhagen, who was not involved with the work.
CN contributed plant material and images and assisted in discussion of a basal angiosperm model plant.
We also investigated the level of PADI2 mRNA in MMTV- Wnt-1 mice, which is a basal mouse model of breast cancer [ 36- 38].
Interestingly, the highest expression in a similar study from Frye et al. using a basal keratinocyte model for MYC activation [ 90] was for the brain and skin protease gene Bssp1, also known as Kallikrein 6 (Klk6).
A Systems Biology Markup Language file of this basal model is provided (Additional file 3) as well as its extension to the overall model (Additional file 4).
When gabarapl1 expression was included in this basal model, low gabarapl1 values were associated with an increased metastasis risk by 3.63-fold in the whole population (CI 1.48 8.93, P=0.005) and by 5.65-fold in the pN+ subset (CI 1.84 17.29, P=0.002).
The basal model was primarily based on experimental data associating the majority of the modeling parameters to experimentally observed electrophysiological data.
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