"It's a balance-of-power issue".
If each pathogen-host combination were to be analyzed separately, realizing that the balance of evolutionary forces acting on the host and pathogen may vary in each case, then treatment would likely become more specific and effective.
Standard evolutionary models explain the maintenance of codon bias through a balance of genetic drift, mutation and weak purifying selection.
This indicates that multiple evolutionary forces are apparent, with sequence variation determined by a balance of conservative and innovative pressures.
There's a balance of both genders.
A balance of power leads to conflict.
A balance of the two is good.
Synonymous codon usage appears to evolve under a balance among weak evolutionary forces in Drosophila and in a wide range of taxa [reviewed in 43], [44], [45], [46], [47], [48].
We derive analytical results based on the so-called House of Gauss approximation for the genetic variance, the mean phenotype, and the mutational variance in the balance of the evolutionary forces.
It is instead suggestive of a balancing evolutionary mechanism, keeping the HEG-containing allele at high frequency although it is usually associated with no fitness advantage for the host.
