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(a) Background model of frame 523.
This advantage allows us to build a background model of relatively few samples, since the classifier is not very sensitive to the robustness of the background model.
This algorithm identifies significantly recurring CNAs using a background model of genomic variability and computes an empirical false discovery rate (q-value) for each candidate CNA.
The searches were fed with the nucleotide frequency matrices (NFMs) of the selected motifs obtained from the MEME search, and a background model of order 1 accounting for single- and di-nucleotide distributions for each set.
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In order to identify the HCGs within each network, we used a background model for the evaluation of the negative and positive coordination in each network, assuming no coordination, and considered genes to be HCGs if their observed coordination was higher by more then six standard deviations from the coordination that was estimated by our background model (for detail see Methods section).
We develop a background model for assessing the significance of tumor-specific alterations, the third core feature of RAE.
We used a background model composed of upstream 2 kb promoter sequences of all known genes and compared them to the upstream promoter sequences of the divergent genes by calculating the log likelihood ratio score to find the putative binding sites.
Again, we used the subset of 11,458 promoters with significant H3K4me3 enrichment to create a background model (Markov model of order 6).
How to initialize a background model is out of the scope of this paper.
As a background model, the whole set of the upstream noncoding sequences of the M. hyopneumoniae genome was used, testing different Markov orders (0 4), since this affects the weight score computation and, consequently, the performance of the matrices.
To take into account the base composition of the promoters a background model from a relevant set of sequences is estimated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com