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The phrase "a backbone upon which" is correct and usable in written English.
It can be used to describe a fundamental support or foundation for something, often in a metaphorical sense.
Example: "The new policy serves as a backbone upon which our entire strategy will be built."
Alternatives: "a foundation on which" or "a support for".
Exact(3)
It therefore serves as a backbone upon which data and its associated metadata can be 'attached'attached
But there is also a backbone upon which a beast of a team is being built.
On the other hand, overexpression or uncontrolled expression of PH-20 can cause great havoc in the extracellular matrix of connective tissues, since the filamentous molecule of HA serves as a backbone upon which other macromolecules associate.
Similar(57)
And, finally, it can act as a syntactic backbone upon which decorations from other domains (say feature structures) can be grafted.
Importantly, endocrine therapy is an important backbone upon which targeted therapy combinations will be built.
A MAP is made up of a hepta lysine backbone upon which are built eight copies of the same peptide sequence (in this case 8 copies of Ro273 289).
For years the Enterprise Service Bus ESBB) has been seen as a corporate integration and messaging backbone upon which application architectures are built.
The first, a pre-produced track, forms MOMENTUM's musical backbone upon which the other layers are generated in real time.
Within the abundant extracellular matrix of articular cartilage, the long, filamentous HA molecules form the backbone upon which the viscoelastic aggrecan molecules align to form aggregates, a supramolecular organization that immobilizes aggrecans at very high concentrations within the collagen network, thereby providing remarkable biomechanical properties to the articular tissue [ 5].
Since the rise of evo-devo as an independent field of study, the body plan concept has formed the backbone upon which much of the current research is anchored.
And General Sisi insisted Tuesday that it would remain "the solid mass and the backbone upon which rest the Egyptian state's pillars".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com