However, there were three interesting findings possibly related to the pleiotropic effects of olmesartan on adipose tissue in KKAy mice: (1) an inhibitory effect on adipocyte hypertrophy, (2) a suppressive effect on IL-6 gene expression, and (3) an ameliorating effect on oxidative stress.
However, from the point of view of possible pleiotropic effects of olmesartan on adipose tissue function, there are three interesting findings possibly related to adipose tissue in KKAy mice: (1) an inhibitory effect on adipocyte hypertrophy, (2) a suppressive effect on IL-6 gene expression, and (3) an ameliorating effect on oxidative stress.
Lastly, modifying the innate immune system of the gut in relation to oral vaccination should be studied with increased stimulation (vaccine plus a mucosal adjuvant such as Escherichia coli double mutant LT [ 124]) to counteract possible tolerance, or with dampening of the innate immunity (vaccine plus a suppressive agent) to determine which approach, if any, has an ameliorating effect.
The exhausted biochar showed an ameliorating effect on the low water and nutrient supply potentials of sandy soil, and thus improved fresh biomass yield and nutritional status of maize seedlings with some restrictions on its high micronutrient content.
Intriguingly, DNP showed a limited extent in improving cognitive impairment in goal-directed behavior, but a significant ameliorating effect in habitual learning in present study.
TNF-α may be required for tissue repair and that it appears to exert a permissive ameliorating effect in our model of acquired lymphedema.
A similar ameliorating effect on stress coping has also been determined by Collins and coworkers [53], by exposing rats to a different form of environmental enrichment, i.e., home cage presence of a running wheel which induces in rodents spontaneous physical exercise.
All the drug treated groups, including TLJN min, TLJN max and DNP, displayed a marked ameliorating effect in the stage of habit learning.
Given large variability of such parameters, we cannot rule out that a potential ameliorating effect of NAC supplementation on endothelial and coagulation activation has been missed due to the small number of included patients.
This theory is supported by the finding that deletion of HIF-2α in both synovium and cartilage exerts a greater ameliorating effect on cartilage destruction than local deletion in cartilage.
