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In addition, an additive effect of a combination therapy of upamostat with gemcitabine was observed in the mammary tumour rat model BN472 (WILEX AG, data on file).
This trend of association was similar to previous finding in renal [ 4] and liver transplantations [ 5] which also suggested an additive effect of the A allele.
In addition, we observed an additive effect of arsenic plus influenza on TGV (Supplemental Material, Table S1).
We have previously demonstrated, using this model, a similar response of an additive effect of burn and disuse on muscle function and bone health [ 30, 31].
The score statistic for testing for an additive effect of a diallelic locus on phenotype is given as U x =(Y− Ȳ) X.
On the basis of retrospective likelihood, the score statistic for testing for an additive effect of a genotyped locus on phenotype is as follows.
Window size of one corresponds to the test of an additive effect of an SNP ('allelic trend test').
Another study in an elderly cohort showed an additive effect of MetS and inflammation markers on heart failure risk (33).
Compared with falls from static positions, this could relate to higher impact forces from an additive effect of an individual's existing motion and the fall-related acceleration.
We noted an altered neuroinflammatory response and an additive effect of HHcy on spatial memory impairment in APP/PS1 mice.
Large-effect QTLs have been also reported in sorghum; for example, Ma1 is a major photoperiod sensitivity locus with an additive effect of 40.3 days [ 65].
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