IPA classifications are based on a curated, literature-derived knowledge base and have multiple levels of specificity; we chose to use the top two classification levels, corresponding to functional categories (level-1) and subcategories (level-2).
The taxonomy was conceptualized as a three level classification system, principal goals of treatment, styles, and techniques.
A three level classification scheme, based on a series of hierarchical PCAs, was used to define genetic groups within species and genetic subgroups within genetic groups.
One reason for this could be a three level classification of the health problem in comparison to 15D which allows the patient to express the problem on five levels.
Wilson and Cleary [ 4] described a five level classification scheme for different measures of health outcome, ranging from biological and physical factors, symptoms, functioning, general health perceptions, through to overall quality of life (QoL).
Either way, it's clearly beyond the threshold for classification as an INES level seven event, although an order of magnitude lower than the 5.2 million TBq released from Chernobyl.
In order to perform a classification at the UV level, two additional probabilities were computed from the model predictions.
As there were few zooplankton in our data set, we do not think that their classification in level two or three is likely to qualitatively alter the results.
At level two of the molecular function classification, most of the terms fell in the 'binding' category (49.0%) or in the 'catalytic activity' category (40.0%).
To effectively compare GO annotations, the terms were normalized to level four of the classification tree.
At the level three of this classification, only two terms were differentially represented among the mapped families and the spruce gene catalogue (FDR ≤ 0.01).
