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Adding PDA ligation as a factor did not improve the logistic model for an adjusted odd ratio of having CLD in ELBW infants who did not respond to a 2nd course of COI.
The incidence of CLD in infants whose DA remained patent after a 2nd course of COI was almost twice that of those whose DA closed with either one or two courses of COI.
Furthermore, due to the small number of patients in our study and the arbitrary nature of the decisions to pursue surgical ligation vs. a third course of COI after failure of a 2nd course of COI, we cannot comment on the potential role of the third course of COI for closure of PDA and the role of surgical ligation in the development of CLD.
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