In a living cell proteins perform their functions not as a single entity but rather work together in the context of networks.
Robin Clarke, fellow of stakeholder engagement at the Office of Public Management, thinks we are seeing a pause as both the voluntary and public sector regroup and reassess how they work together in this very different context.
The notion of HIF and TGF-β1 working together in the context of CKD is furthermore supported by the observation that hypoxia synergizes with TGF-β1 with regard to the production of certain collagens [ 40, 41].
The programme represents a novel approach to using relevant available data and expertise from health and law enforcement professionals working together in the context of a statutory, local government level partnership to develop violence prevention strategies.
"For the first time in our history the parties are learning to work together in a democratic context".
We must consider how our programmes and partners work together in a broader context, rather than as 'stovepipes' or 'areas of interest'".
We must consider how our programs and partners work together in a broader context, rather than individual "stovepipes" or areas of interest.
By carefully extracting the relevant signal in thousands of heterogeneous functional genomics experiments through integrative analysis, these networks model how genes work together in specific contexts to carry out cellular processes, thereby contributing to a molecular-level understanding of complex human disease and paving the way toward better therapy and drug treatment.
The idea is to model all the causes that contribute to a natural history so as to explore how they work together in different contexts to produce the various outcomes of interest, and then understand patients as idiosyncratic instances of the exemplar.
This may be achieved through partnership working between those who have historically not worked together, or between those who currently work together in different contexts.
Although we have a relatively complete "parts list" of the proteins that connect input sensing to cell responses, we are only just starting to understand how they work together in specific cellular contexts.
