This practice, Löwy finds, later led to surgical interventions for women with a hereditary predisposition to cancer but no detectable disease.
Suppose the natural history of a chronic disease can be defined by three states, including normal (no detectable disease), asymptomatic (preclinical screen-detectable disease) and symptomatic (clinical disease).
We found another nine cases of ocular TB with no systemic detectable disease and normal chest radiograph, but in three of them strong TST reaction was noted and in a fourth patient non-reacting TST was attributed to pregnancy [1 8].
Disease-related choroidal inflammation on ICGA was highly prevalent even among patients under systemic treatment as well as among those with no clinically detectable disease activity, thus confirming previous studies in European and Asian population and reinforcing the usefulness of ICGA to assist monitoring disease activity to better tailor treatment strategies.
BUN was measured in freshly drawn cardiac blood (Azostix reagent strips, Siemens Healthcare Diagnostics Inc .. BUN of 5 15 mg/dL was considered consistent with no detectable renal disease, 15 26 mg/dL consistent with mild disease, 30 40 mg/dL consistent with moderate disease and 50 80 mg/dL consistent with severe disease.
In the first three cases, all patients have a normal GFR despite differences in their functional renal mass, while a low GFR is observed in the fourth case in a young vegetarian female with no detectable renal disease.
Thus, until the performance of a candidate marker is evaluated with specimens from women with asymptomatic, early stage cancer, its value as an early detection marker remains hypothetical, and researchers must be cautious not to overstate their claims when assays have only been tested on samples from women with clinically detectable disease [29].
In immunocompetent individuals CMV infections are of chronic or latent type and are usually not associated with clinically detectable disease.
Sixteen patients had acute leukemia, of which 10 had detectable disease (2 in morphologic remission with molecularly detectable disease, 8 with active disease - median 19%) at the time of HCT.
