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The sentence "What's wrong with you?" is grammatically correct and can be used in written English
It is typically used when asking someone about their current state or behavior. Here are some examples of when you could use this phrase: 1. When you notice a sudden change in someone's mood or behavior, you could ask them, "What's wrong with you? You seem upset." 2. If someone is acting differently than usual, you could ask them, "What's wrong with you today? You're usually so cheerful." 3. In a more confrontational situation, you could ask someone, "What's wrong with you? Why did you say that?" 4. If someone is physically injured or unwell, you could ask them, "What's wrong with you? Do you need help?" Overall, "What's wrong with you?" is a versatile phrase that can be used in various situations to inquire about someone's current state or behavior.
Exact(60)
I once screamed: "WHAT'S WRONG WITH YOU?" at him (OK, that was yesterday, too).
"What's wrong with you?" he demanded.
"What's wrong with you?" she asked.
"What's wrong with you?" Joanne asks.
"What's wrong with you?" someone asked.
"What's wrong with you, Tom Mauricece screamed.
"What's wrong with you?" she screamed.
"What's wrong with you?" cried Little Em'ly.
"What's wrong with you?" she says.
"What's wrong with you!" she scolded, tugging on his sleeve.
"What's wrong with you?" The class has one benefit.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com