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Multiple mechanisms appear to contribute to the decreased DIO2 activity, including weakened expression of DIO2 mRNA, competitive inhibition of DIO2, and enhanced post-translational degradation of DIO2.
By 8 days, low-dose 4OHT-treated SGs were hyperplastic, exhibiting weakened expression of FASN and increased proliferation.
Forty-four prothens, thexpressionof of which is higher in a situation of proper biofilm formation, and 13 proteins of weakened expression were identified using electrophoretic techniques [ 13].
The null mutant of dPob shows quite characteristic phenotype; no detectable protein expression of Rh1, and very weakened expression of other multiple-transmembrane domain proteins such as Na+K+-ATPase or TRP in the mosaic retina.
The null mutant of dPob shows a characteristic phenotype with no detectable protein expression of Rh1 and very weakened expression of other multiple-transmembrane domain proteins such as Na+K+-ATPase in the mosaic retina (see below).
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This is likely secondary to weakened Ihh expression in the cartilage of the Catnbc/c; Col2a1-Cre mouse embryo [9], [14], since ligand-independent activation of Hedgehog (Hh) signaling in the Catnbc/c; Col2a1-Cre mice rescues PTHrP expression [12].
That is, in the case of weakened enhancers, expression of the reporter gene was maintained at different levels in different clones and varied significantly among cells within individual clones.
To compensate for the weakened Leu2 expression, S. cerevisiae selects for significantly higher plasmid copy number [ 15].
Later embryos in which anterior Nv eve stripes are beginning to fade exhibit overlap of mitotic figures with weakened Nv eve stripe expression.
We conclude that variegated expression requires a weakened, but non-zero, enhancer.
The present case of expression from a weakened enhancer closely resembles the behavior of the IL4 gene, in which many different levels of expression are possible [4].
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