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We observed coordinated increases in the expression levels of these four genes in the brain of the schizophrenic subjects.
We observed coordinated changes in the expression of a large number of genes involved in energy metabolism and responses to oxidative stress.
We observed coordinated changes in the expression of a large number of genes involved in energy metabolism and cellular responses to increased ROS levels.
It also seems likely that some of the global shifts in gene expression across stages reflect changes in broad functional demands of developmental processes as we observed coordinated changes in particular functional classes of genes.
Interestingly, many of these genes are related to metabolic processes and translation, categories that were also enriched in Cluster 2. Together, these results indicate that stage-specific shifts in gene expression may reflect specific functional demands of individual developmental processes as we observed coordinated changes in enriched functional classes between clusters.
Interestingly, we observed coordinated suppression of AR expression, mediated through c-Myc/Max heterodimer and/or AP4 homodimer, and AP4 has been shown to be a conserved and direct target gene of c-Myc (Cole & McMahon 1999, Jung et al. 2008).
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We observed coordinate events in transcript regulation upon treatment of human hepatocytes with Aroclor 1254 and identified a regulatory gene network of different TFs acting in concert.
During reproductive behavior also, we have observed coordinated and collective behaviors in surface fish (personal observations).
We have observed coordinated movement within the junction region with feeding behaviour (LaJeunesse unpublished observations), and the muscular linkage between the junction region and the gastric caeca may serve as a physical connection between these two regions of the gut (Fig 5A).
We also observed coordinated activation of additional canonical apoptotic markers, including phosphatidylserine exposure.
The P-loop is seen forming the SO4 2− binding pocket and an Mg2+ is observed coordinated by T227, K231 from P-loop and E345 from motif II (Fig. 1E).
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