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Validation of this concept should be considered in the context of a regional therapy clinical trial.
Due to its very restricted role in immune regulation, JAK3 was promoted as an excellent target for immunosuppression for more than a decade, but clinical validation of this concept is still elusive.
However, the lack of prospective validation of this concept in the setting of an appropriate clinical trial renders its clinical application difficult.
Collectively, our findings on aging-associated expression of cell cycle regulatory proteins are in line with a role of reduced proliferation capacity of aged fibroblast discussed in skin aging and provide candidate proteins for further functional validation of this concept.
A new study provides further preclinical validation of this concept by demonstrating that BRCA1-deficient mouse mammary tumor cells are selectively sensitive to an inhibitor of the polycomb gene EZH2.
Given that many of the currently available drugs are potentially capable of stimulating IFNAR1 ubiquitination, the validation of this concept and practical applications to eliminate IFNAR1 in acute life-threatening inflammatory syndromes is likely to be imminent.
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For a reliable validation of this technological concept thorough experimental and numerical investigations are necessary.
Validation of this new concept is performed by designing an implementation addressing foreground extraction from videos captured by freely moving cameras.
The SLP was flown for the first time onboard the DEMETER satellite for in-flight validation of this novel concept, but the main sensor used routinely during the mission is the cylindrical probe.
This paper is about the experimental validation of the concept.
This paper demonstrates the manner in which ad-hoc instrumentation of a TCC specimen can underpin validation of that concept.
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CEO of Professional Science Editing for Scientists @ prosciediting.com