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Thus, it is expected that, when the scale has been finally validated (phase 3), it may be used by managers and healthcare professionals to diagnosis the coordination of their systems, allowing weaknesses to be identified and improvements to be promoted, through recommendations, aiming to reorganize the systems in order to make them more equitable, efficient and resolutive.
To facilitate translation of this work, we deliberately chose clinically validated (phase II/III) glycolysis inhibitors, for which the posology and safety characteristics are already known, and one of the most popular clinically licensed photosensitisers (Brawer, 2005; Morton et al, 2008; Dwarakanath, 2009).
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Whether validating phase measurements by computing statistics over A-lines or averaging over A-lines to reduce the impact of phase noise, a method for unwrapping spatially wrapped phase measurements is critical.
During the model validating phase II (July 2009 to January 2010), premenopausal women, aged 18 45 years, were recruited using the same inclusion and exclusion criteria as in phase I; they completed the same 25-item questionnaire before their surgery.
The levels of salivary 17 β-estradiol and progesterone were measured to validate phases retrospectively.
rs35415 (p-value 0.0004 in phase I) was selected as the tag of the LD block located at the 5' end of the gene, while rs35414, studied in phase I and validated in phase II (global p-value = 0.0001), is located in a region without apparent LD block structure (Figure S1).
However, biomarkers that have been completely validated during Phase II for use in Phase III trials are often unavailable [ 11, 12].
Phase I is designed for rapid selection of candidate biomarkers, which are then validated in Phase II.
Both bag and chain intrafusal fibers were generated and subsequently validated by phase microscopy and immunocytochemistry.
The accuracy of the developed finite element simulation strategy is validated for phase proportion and hardness distributions through the wide-band LSM on roller steel with proper instrumentation for data measurement.
These key components were validated in Phase 2 and then extended through focus groups with bereaved parents.
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