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Access to supervisory-level data could be investigated as a means to validate observed model work group size findings.
We used proteomics, systems biology, and immunohistochemistry to explore protein expression in human endometrial tumours, to identify deregulated regulatory mechanisms, and to validate observed changes in protein expression using tissue microarrays.
However, more research is needed to experimentally validate observed differences and demonstrate that lack of thermodynamic consistency may indeed result in inaccurate (or even false) biological predictions.
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This is a novel method of validating observed associations involving genetics and observational epidemiologic data.
Then we validated observed associations in an independent Spanish series, making this the largest sporadic MM susceptibility study in the Spanish population up to now.
Second, the method can only validate previously observed associations; consequently, the inability to validate an association does not imply that it is false, it may simply be unknown (see the Discussion section).
To validate whether observed signals were due to propagation delay in the troposphere or not, we generated other ScanSAR interferograms acquired at different times.
To validate signals observed on our microarray and differences between High and Low LG offspring, we quantified changes in H3K9 acetylation, DNA methylation, and transcription.
These results also validate the observed in vivo BLI results described above.
To validate the observed 24-hr gene responses, we selected transcripts that we have previously shown to be regulated by E2 (Hewitt et al. 2003, 2005, 2006).
Fisher's exact test was used to compare read-count log ratios derived from RPKM values to statistically validate differences observed in gene expression levels between the primary ALL and relapse samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com