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The realized selection response for F can be compared with the theoretically expected one if selection has been done with the conventional combined selection index although that prediction of response is valid in principle for only one generation of selection.
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To the extent that she's not doing her fair share of society's workload, we might be able to address this by drafting her to perform some community-service work every month; that's a perfectly valid solution in principle.
Without addressing that issue, La Forge argued that even radical dissimilarity could not constitute a valid objection in principle to the efficacy of a putative cause; otherwise God, the supreme cause of everything, could not cause creatures that are so dissimilar to his nature (T 213; THM 124).
I think this is a valid concept in principle.
This argument is valid and in principle allows much earlier use of interesting new medicinal products, especially in the case of tracers of which only nanomolar amounts have to be administered once or a few times, thus entailing minimal risks of toxicity or side-effects.
In Experiment 1a it was tested whether multimedia design principles (multimedia principle, modality principle, redundancy principle) are valid in hypermedia environments, despite the fact that hypermedia offers more learner control than multimedia.
The preceding views were dominant in the German society at the time and were sanctioned by the Court in the Saxon Wood Pulp case, where the Court essentially upheld the proposition that cartel agreements are in principle valid and enforceable agreements under German law.
This reasoning suggests us to exclude from the exogenous tax series those measures adopted under periods of high financial turmoil, whereas reforms adopted to tackle the budget deficit under milder financial conditions and specially those with large implementation lags are in principle valid to be included in the exogenous tax series.
This issue is not surprising as the lin-log kinetics are derived from thermodynamics concepts and are in principle valid only around steady state (or reference state) [ 20].
These conclusions are in principle valid and important, however there are several concerns: 1) The authors conclude that 77% of the tagged lines are functional as 88 of 114 protein traps in (predicted) essential genes are viable.
The act in question does undoubtedly discriminate in favor of a certain class of refiners, but this discrimination, if founded upon a reasonable distinction in principle, is valid.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com