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Using a rational approach to the design of antifungal agents, a series of azole agents with 1,3,4-oxadiazole side chains were designed and synthesized.
Using a rational approach, which targets a panel consisting of a few hundred genes, considered to be "actionable" and/or "driver", it is possible to sequence and characterize a tumor, depending on its major molecular characteristics.
Using a rational approach, we designed a 7-amino acid peptide activator of PKCε, derived from an HSP90 homologous sequence located in the C2 domain of PKCε (termed ψεHSP90).
An appropriate formulation of this prodrug has been designed using a rational approach combining different physicochemical techniques.
This review describes the preparation of white-light emissive materials using a rational approach based on dynamic polymerization in supramolecular chemistry.
Best possible drug candidates have been proposed using a rational approach employing a pipeline of computational techniques namely MetaPrint2D prediction, molinspiration, cheminformatics, Osiris Data warrior, AutoDock and iGEMDOCK.
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Aiming to develop new antileishmanial lead compounds, we used a rational approach to synthesize a new set of sulfonamide 4-methoxychalcone derivatives (3a 3i) and evaluate the sulfonamide and methoxy moieties as promising adding-groups to chalcones.
The final theme used a rational approach to support smoke-free behaviours; messages recognised smokers' autonomy and promoted children's right to a smoke-free life.
To overcome this limitation, we used a rational approach to engineer ligand recognition properties similar to the 5-HT3R ECD into the AChBP scaffold.
The imprinted polymer was developed using a rational design approach, and pre-polymerization interactions were investigated using molecular dynamics simulations and X-ray crystallography.
Eight variants of creatine kinase were created to switch the substrate specificity from creatine to glycocyamine using a rational design approach.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com