But his idea of a "difference engine," a hand-cranked device that could solve mathematical problems, is essentially the first instance of a computer in human history.
In this study, we report the first instance of a ribozyme that demonstrably folds differently upon nondenaturing and denaturing purification.
Upon him alone was imposed the responsibility, in the first instance, of making rules and regulations for the 'proper and economical execution' of the statutes in question, through agents whom he should designate.
However, this decree proved challenging upon the first instance of its application.
The first instance of gubernatorial succession in Kentucky's history occurred upon the death of Governor George Madison in 1816.
Two main problems arise for noncausal accounts of free will; both are problems, in the first instance, for noncausal accounts of intentional action.
(Alexander, 75) For Alexander, self-monitoring was highly dependent, in the first instance, upon recognising that a health problem exists.
In other instances, we have left of the problem of jurisdiction to be determined in the first instance by the administrative agency.
In the first instance problems with delayed recall do not seem to reflect a fundamental problem with recall more generally.
Anke Neibig Newcastle upon Tyne That the Guardian does not in the first instance call the Nazi camps "German" is not a sign of "worrying political correctness".
So long as that intuition is in play, the problem indeed arises for true propositions, in the first instance, and then for facts by transitivity of identity.
