Upon receptor activation, the signal is transmitted intracellularly by stabilization of Armadillo (Arm)/β-catenin.
Upon receptor binding, when the interactions with clathrin and AP2 come into play, the C-tail of arrestins is released and becomes even more disordered.
Upon receptor binding, cyclo 1-10)[Pro1, d-Leu6, BABA10] LHRH causes testosterone release in C57/B16 mice (in vivo efficacy) that is comparable to that of leuprolide.
Upon receptor activation, the adaptor molecules such as FAS-associated death domain protein (FADD) are recruited to associate and activate caspase-8 or caspase-10, which leads to the cleavage and activation of caspase-3 and caspase-7.
Upon receptor T cell (TCR) stimulation, NKT cells are able to rapidly secrete both Th1 and Th2 cytokines [12].
Upon receptor engagement, K63-linked ubiquitin chains are affixed to TRAF6, at least in part through the E3 ubiquitin ligase activity of the TRAF6 RING finger domain.
Upon receptor activation, conformational changes reveal phosphorylation sites on the C-terminus.
Upon receptor tyrosine kinase activation, the PI3K kinase phosphorylates inositol lipids to phosphatidylinositol-3,4,5-trisphosphate.
Upon receptor activation, JAKs phosphorylate transcription factors known as STATs and initiate the JAK-STAT signaling pathway.
Upon receptor activation, Mg2+ is displaced, which allows Ca2+ and other cations to move into the cell.
Upon receptor binding, EGF triggers cascades of downstream signaling, including the MAPK and phosphoinositide-3-kinase (PI3K /Akt signaling pathways.
