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Discover LudwigThe phrase "unfamiliarity with" is correct and can be used in written English
It is used to indicate a lack of knowledge or experience with something. You can use it when describing a situation or topic that is new to you or someone else. Example: "The students struggled on their first test due to their unfamiliarity with the new curriculum." In this sentence, "unfamiliarity with" is used to explain the reason why the students had difficulties on their test – because they were not familiar with the updated course material.
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Unfamiliarity with English is just one characteristic that depresses those students' SAT verbal scores.
Unfamiliarity with starting insulin therapy was also highlighted.
Unfamiliarity with the signs and symptoms of sepsis may further hinder accurate diagnosis.
Unfamiliarity with some ultrasound formats Images from many different manufacturers were used.
On the other hand, an unfamiliar prefix can signal unfamiliarity with this neck of the woods.
"Manhattan?" betrays unfamiliarity with the geography of New York State.
Their unfamiliarity with life in Britain makes them doubly vulnerable.
Hall's unfamiliarity with the university was not surprising.
He again approached Kurzel, who again agreed, despite his unfamiliarity with the source material.
The board said a contributing cause of the accident was the driver's unfamiliarity with the bus.
Despite Dr. Radebaugh's embarrassment, his unfamiliarity with the woman's condition was hardly surprising.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com