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Although formally designated as "unknown etiology," under the existing paradigm an accumulation of a number of somatic mutations greater than some threshold not yet defined is considered to be the principal triggering factor.
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According to the existing paradigm, under normal unstressed conditions mTORC1 activity mirrors the levels of its positive stimulators, and thus gradually decreases during fasting.
The existing paradigm serves to rigidify decision-making at a time when extraordinary flexibility and rapid change are essential.
The existing paradigm doesn't capture the full picture — especially the financial crisis and the aftermath.
"Americans want to preserve the existing paradigm," a diplomat from another country said.
Until a new model is agreed upon and rolling, we can be the best at the existing paradigm, but until the paradigm shifts, it's going to be a declining business.
The existing paradigm suggests that this is due to the seasonal variation of the surface heat fluxes.
I show why we must waste no time in rejecting the existing paradigm that got us into this catastrophic mess.
Working ever more diligently within the existing paradigm leads to frustration, not progress.
The revolutionary search for a replacement paradigm is driven by the failure of the existing paradigm to solve certain important anomalies.
Any replacement paradigm had better solve the majority of those puzzles, or it will not be worth adopting in place of the existing paradigm.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com