Exact(22)
No significant SNPs were identified under linkage peaks derived from sib pairs in the same cohort [14], [23].
All genes under linkage peaks with a LOD score ≥2 were located by converting genetic map (deCODE) cM numbers to human genome chromosome physical positions and then using the NCBI database (Build 36).
Sixteen of the 20 deletions had a maximum r2 value, within a 50 kb window either side of the deletion, which was significantly greater (α = 5%) than expected under linkage equilibrium (Table 1).
Approaches in between the extremes include: candidate gene and regulatory region sequencing, population-based approaches to linkage analysis using IBD sharing [92], using long-range haplotype phasing to select cases for sequencing near tagSNPs [86], [89], targeted re-sequencing under linkage peaks [79] and whole-exome sequencing [4].
They show how neutrality emerges for strong adaptive evolution under linkage.
Note that this expression reduces to the classical one [ 15] under linkage equilibrium.
Similar(38)
Non-differential under-linkage or under-reporting could lead to underestimation of vaccine effectiveness.
22 We believe that under-linkage is likely to have occurred infrequently and to have been non-differential for cases and controls.
Some degree of under-linkage (failure to correctly assign a woman's vaccination record to her smear test record) may have occurred during probabilistic linkage between registers owing to possible address or name changes as a result of marriage in this particular population.
For an equation type-independent parameter of probabilistic choice, we adopted AUC, which is defined as the normalized area under the linkage of indifference points (i.e., subjective values) at each odds against (= (1- probability)/ probability [ 11]).
For each individual, three phenotypes were simulated, a phenotype for the first trait, a phenotype for the second trait under the pleiotropic assumption and a phenotype for the second trait under the close linkage assumption.
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