Exact(19)
Two testes were cultured in 500 μL medium containing either vehicle [dimethyl sulfoxide (DMSO)] or a test compound.
One of these sacs in the male encloses two testes and a number of cement glands.
The mammalian scrotum has two testes that hang below the warm body cavity, lowering temperatures to the point that sperm production is possible, at least for animals like cats and dogs, cows and horses, rats and bats -- and humans.
The two testes are made up of a variable number of follicles in which the spermatocytes mature and form packets of elongated spermatozoa.
In females, the two ovaries are situated in the pelvic cavity; in males, the two testes are enveloped in a sac of skin, the scrotum, lying below and outside the abdomen.
The two testes, or testicles, which usually complete their descent into the scrotum from their point of origin on the back wall of the abdomen in the seventh month after conception, are suspended in the scrotum by the spermatic cords.
Similar(41)
Males produce sperm, usually as a milky white substance called milt, in two (sometimes one) testes within the body cavity.
At least four testes from mice of each genotype were examined at each developmental stage.
Quantitative data analysis of the TUNEL assay showed that p53−/−Ing2−/− testes had higher levels of apoptosis than Ing2+/+ and p53−/− testes but lower levels of apoptosis than Ing2−/− testes (Fig. 5A), suggesting that Ing2 deficiency induces apoptosis in a p53-dependent manner, which is consistent with p53 induction in Ing2−/− testes (Fig. 4), as well as in a p53-independent manner.
We injected undifferentiated OSKM and OSKMV iPSCs into seminiferous tubules of eight testes each to evaluate their potential to form PGCs, gonocytes or spermatogonia in vivo in a transplant assay.
Testes injected with OSKMV cells maintained their naïve tissue structure 2-month post injection and one of eight testes was positive for a cluster of human cells that persisted long term (Fig. 3A, right panel and Supplementary Material, Table S3).
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