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The proposed tool was designed and is being developed with the support of two TCM therapists, which act as experts and provide aid to the processes of building the knowledge base and the automatic diagnosis system.
The exceptions were the opinions of two TCM acupuncture officials.
The top two TCM compounds can be selected (Table 1).
For the top two TCM compounds, saussureamine C and precatorine were extracted from Lycium chinense Mill.
For the other two TCM candidates, diiodotyrosine and saussureamine C maintain the similar docking poses under dynamic conditions.
They indicate that two TCM candidates remain the H-bonds with residues Lys311 in chain A of PKM2 protein.
Similar(39)
After molecular docking and ranking by docking score, the top three TCM compounds are defined as candidate compounds which are Saussureamine C, 5-hydroxy-L-tryptophan, and diiodotyrosine derived from the TCM herbs Saussurea lappa Clarke, Mucuna pruriens (L) D., and Ox Thyroid of Bos taurus domesticus Gmelin (or Bubalus bubalis L ., respectively (Table 1).
Design: Under a Latin square design, six TCM acupuncturists evaluated the same six patients on the same day.
Four common metals: copper, aluminum, stainless steel 316, and carbon steel, and five TCM: CaCl2, Na2S, CaO, MgSO4, and MgCl2, were studied.
Total 200 inhibitors from TCM against co-chaperon p23 were screened and only four TCM compounds like dihydro-n-caffeoyltyramine, lithospermic acid, oleuropein and salvianolic acid were selected for further analysis, which showed binding energies, − 6.0, − 6.6, − 6.2 and − 6.7 kcal/mol, respectively.
We also calculated the solvent accessible hydrophobic and hydrophilic surface areas for the three TCM compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com