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To determine whether expression data from purified cells result in improved clustering, we analysed monocyte-derived microarray data from 13 SLE patients, 44 AAV patients and 25 normal controls (two SLE samples failed quality control).
Studies from our laboratory and from others have used more extensive microarrays than those used in the two SLE studies described above to characterize the broad gene expression profile operative in the peripheral blood of patients with SLE [ 3- 6].
However, although successfully confirmed to be useful in major large scale trials in RA and vasculitis, two SLE trials did not meet their endpoints.
No two SLE patients or two controls are blood relatives to avoid intrafamilial correlation bias.
MDDCs from two healthy donors and two SLE subjects, exposed or non-exposed to 1, 25 D were incubated with activating SLE plasma or control plasma for 4 hours.
All patients and controls were Caucasians, except for two SLE patients of Asian origin.
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Based on KKT conditions of NLSDP (1.1) and techniques of perturbation, we construct two SLEs skillfully.
Based on KKT conditions of nonlinear SDP problems and techniques of perturbation, we construct two SLEs skillfully.
Through in-depth analysis of the double rotating hinge connected by two SLEs, the mechanism theory in the constitution of elements of the deployable structure has been revealed.
First, for problem (P) with no equality constraints, i.e., (I^{ell }=emptyset ), in 1987, Panier et al. [22] presented a QP-free algorithm denoted by PTH, at iterate k, two SLEs are solved to yield a master search direction.
At each iteration, the search direction is yielded by solving two SLEs with the same coefficient matrix; some penalty function is used as the merit function for line search and the penalty parameter is updated automatically in the algorithm.
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