Exact(4)
With each of the two PTP links connecting the base station to the IP-backbone in clock- or anti-clock-wise direction within the ring topology, if one SBC fails the second SBC will still be operational.
A typical deployment to serve a medium sized community would provide four radio sectors for PTMP user access and two PTP links for back-haul, requiring a total of six radios.
However, two PTP genes were identified in the genome of T. parvula (Table 4).
Moreover, from RNA-seq and real-time PCR data, it was interesting to find that the other two PTP genes, ZmPP54 and ZmPP59, whose expression levels were also up-regulated.
Similar(56)
Considering that the complex of non-truncated PTP-SL contains one ERK2 molecule and two PTP-SL molecules, the experimentally determined MW represents 84% of the theoretical value of this heterotrimer.
Results of the cross-linking experiments, combined with SDS-PAGE and MALDI-TOF analysis of the cross-linked products, as well as the results of gel-filtration experiments on PTP-SL and its complex with ERK2, support the idea that the complex is a mixture of heterodimer and heterotrimer (composed of two PTP-SL and one ERK-2 molecule).
To examine whether these PTPs have synergistic effects on Stat3 dephosphorylation after UVB irradiation, two PTPs (TC-PTP and SHP1, TC-PTP and SHP2) or all three PTPs were simultaneously knocked down in mouse keratinocytes using RNAi.
Furthermore, simultaneous knockdown of all three PTPs in keratinocytes reduced dephosphorylation of Stat3 in response to UVB irradiation to a greater extent compared to knockdown of only two PTPs as well as knockdown of TC-PTP only (Fig. 6).
It is possible that the absence or reduction of each PTP can be compensated by activation of other two PTPs after UVB irradiation.
In this regard, the level of phosphorylated Stat3 was significantly increased in keratincytes transfected with siRNAs of two PTPs compared with the level seen in keratinocytes transfected with TC-PTP siRNA only (Fig. 6).
The phosphatase and sulfatase activities of each of the two PTPs were inhibited equally by inorganic arsenate, providing evidence that both activities are catalyzed by the PTPs and take place in the same active site.
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