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Two MCR were found.
Two MCR were observed in more than 10% of t-AML (table 8).
As shown in Table 1, out of eight MCR that did not overlap with previously reported gains, one MCR contained a single gene (MCOS2) and two MCR contained only three genes.
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The differences between the two MCRs could simply arise from changes in their metabolism.
It is also possible that the two MCRs are incorporated into different types of posttranslational modifications.
For example, if the two MCRs are metabolized at different rates, a different subset of proteins could be modified after the same length of labeling.
Somatic mutations in TP53 plus two MCRs (deletion of CDKN2A/ 2B and amplification of CCND1) point primarily to cell cycle deregulation in over 65% of the cases examined.
Nine MCR contained between 1 and 5 coding genes, five MCR between 7 and 9 coding genes, and four MCR more than 10 coding genes.
Four of these MCR contained a single gene (NSUN3, KHDRBS2, SNTG1 and ST18) and one MCR contained four genes.
As shown in Table 2, six MCR of loss did not overlap with previously reported losses.
Three MCR were reported in more than 10% of t-AML (table 8).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com