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Two GCs (GC A and GC B) were excised and the rearranged VH genes amplified (as described under Materials and methods).
Whether this difference might be explained by regulation of different genes by the two GCs has never been addressed.
The findings in these latter two GCs suggest that FGFR2- and HER2- amplified tumour cells may have developed from different tumour cell clones with differing genetic characteristics.
Thus, the M- and/or p-values for 181 of the 208 genes found to be significantly regulated by only one of the two GCs were just below the cut-off for the other GC (see also Figure 3).
Although many clinical studies comparing the effects of PRED and DEX have been conducted, to our knowledge, the differences between the two GCs have not been investigated on a molecular level.
A high correlation of GC-regulations was observed (R = 0.84, Additional file 1: Figure S4) that was even higher when only genes found to be significantly regulated by one of the two GCs using the above cut-off criteria (R = 0.98, Figure 2B) were considered.
Similar(52)
Later the peloton split as it swept around a giant roundabout and there were crashes on both sides of the road, including two GC contenders Alessandro Valverde and Teejay van Garderen.
If you look at other teams, they've got a sprinter, they've got two GC riders, they're trying to put guys in the break for stage [wins]," Froome said last week.
Moreover, we discovered two GC boxes in the TFF2 promoter and confirmed the specific binding of SP3 to this promoter.
This region contains two GC-rich motifs and a CT box, regions for potential transcription factor interaction.
There is growing interest in the possible role of two GC-induced proteins (Annexin A1 and GILZ) in the anti-inflammatory effects of GCs in vivo.
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