Exact(4)
We have previously seen that one rigid guidance cue molecule, netrin-1, binds two DCC receptors (Finci et al., 2014).
They conclude that the two DCC isoforms are functionally distinct, and the Netrin-1/DCClong interaction functions for axon outgrowth and guidance (Leggere et al., 2016).
To further evaluate the role of other DCC components in dauer regulation, we reduced the activity of two DCC components via genetic mutation.
Developing a working solution was more critical than maintaining a commonly shared generalized solution during the early stages of the project, resulting in the two DCC's submission pipelines bearing only a superficial resemblance.
Similar(56)
We therefore conclude that the DCC short isoform shows reduced netrin-1 binding, because it cannot use all possible combinations of the three DCC binding sites present on netrin-1.
Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21CIPI) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined.
Table 1 The surface buried area of the four DCC FN4 domains on FN56 FN4-A 1,106 Å2 FN4-B 144 Å2 FN4-C 748 Å2 FN4-D 195 Å2 Note: Out of the 4 potential FN4 domains that pack around FN56, the FN4-A has the largest surface buried area indicating that it makes the largest contact with FN56.
In general, DCC density and DC clustering decreased in response to all the activity inhibitors tested, with variations among the three DCC groups being observed (Figures 3e, 3f).
Our comparison showed that the abundance of the three DCC classes (normalized per total dendritic length) in culture was higher than in the simulations, as shown in Figure 3d.
Altogether, 80% of the scheduled samples were obtained, resulting in a total of 416 samples from the three DCC rooms.
The attendees account for 74%, 26% and 40% of the mean number of children (34, 69, and 45) attending the three DCC's.
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