Exact(1)
Two CPIs are inserted into the tokamak vacuum vessel and these components shall be operated at 90 K for the liquid nitrogen thermal shields and 4.5 K for the hydrogen cryo-panel.
Similar(59)
At day 3 after diagnosis the population was divided into two groups: patients with CPIS ≥ 6 (group 1, n = 5) and patients with CPIS < 6 (group 2, n = 10).
The CPIS incorporates five variables: temperature (T°C), white blood cells (WBC), tracheal secretions, pO2/FiO2 and RX.
However, only those with a 'modified' clinical pulmonary infection score (CPIS) of five or greater, provided empirical antibiotics were delivered promptly (that is, day 1), were kept for analysis in the present work, as in the recently published 'STATIN-VAP' study, in order to include the patients with a sufficiently high level of suspicion regarding VAP diagnosis [ 22, 24, 25].
Also, as pneumonia cases we included those patients with a CPIS higher than six [ 16].
Seventy-four episodes were excluded because of missing data (n = 22), inclusion in a RCT comparing atorvastatin to placebo for the management of VAP (n = 52), CPIS less than five or the absence of antibiotics delivered on day 1 (n = 208).
An episode of VAP was defined as a Clinical Pulmonary Infection Score (CPIS) of more than six [12, 13].
Diagnostic accuracy was compared between the biomarker models and the CPIS and the slope of the CPIS.
Singh et al. [ 66] used a modified CPIS (calculated at baseline from the first five clinical variables, and CPIS at 72 hours was based on all variables of the score) that antibiotics were stopped in patients with a persistent low score (<6) after 3 days of therapy, avoiding unnecessary use of antibiotics, and all patients who discontinued the therapy improved.
In summary, we found that the combination of two cheap and widely available tools, CRP and CPIS, could be very helpful in the approach of patients undergoing mechanical ventilation with risk of VAP but always in combination with the available clinical data.
Furthermore, the mean distribution of CPIS values during antibiotic treatment for the first seven days of the study was similar for the two treatment groups, only separating after completion of therapy in the doripenem arm.
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