Finally, although several vasoactive drugs cause cranial arterial vasodilation and subsequently trigger migraine, including nitroglycerin [76], CGRP [14, 85], and PACAP [11, 124], VIP [11, 114] does not trigger a delayed migraine headache in patients.
Indeed, in a recent preclinical study it was found that both VIP and PACAP similarly cause short-lived (1 5 min) vasodilation of meningeal arteries, yet only PACAP was able to trigger a delayed, by 90 min, activation and sensitization of central trigeminovascular neurons [5].
While remnants of the chemical agents used in the cross-linking ("stabilizing") process could trigger a delayed inflammatory reaction, it is more likely that the chemical cross-linking process itself, which reportedly modifies the structure by 0.6%1.0%%, (Andre 2004), introduces an immunogenic potential by inducing changes in the three dimensional structure of these molecules.
The buyback comes the day after News Corp triggered a delay to its plan to buy the 61% of BSkyB it does not already own.
Such retaliation is encouraged by a twist in the law that triggers a delay in the regulatory approval of any generic drug of up to 30 months if a lawsuit has been filed.
As a general principle, DDR triggers a delay in cell cycle progression to permit DNA repair, or if the damage is too extensive, increased cell death (Reinhardt and Yaffe, 2009).
We surmise that even at the permissive temperature the erg26 mutant is defective in the sterol composition of its cellular membranes and thus triggers a delay in the START of G1.
This reversibility can be seen while decreasing the storage level to the permitted range, which triggers a delayed reduction of the seepage water to the pre-incident level.
'Sham' stimulation triggered a delayed cluster headache attack (> 1 24 h) in 75% (15/20 patients) compared to 70% (14/20 patients) in the LFS group.
