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Anorexia was the most common adverse event of IA chemotherapy in most cases (7 out of 12, 58%) and usually was tolerable (grade 1 or 2) (Table 2).
Up to January 2011 all control examinations showed good tumor regression under continuous sorafenib medication with tolerable (Grade 1 2) side effects.
A further randomised study of CAPOX plus bevacizumab vs CAPIRI plus bevacizumab using a lower dose of capecitabine and irinotecan resulted in a more tolerable grade 3 4 rate of 16 (CAPOX) and 13% (CAPIRI) respectively (Reinacher-Schick et al, 2008).
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Skin toxicity was graded according to the following scale that was based on patient tolerability: Grade 1 – a tolerable rash that did not require any symptomatic treatment.
Although both depsipeptide and MGCD0103 were tolerable, haematological grade 4 toxicity was observed with both drugs.
The majority of non-haematologic toxicities were mild and tolerable without grade 3 or 4 non-haematologic toxicity.
I imagine there must be a long compound word in German for the pleasure that can attach itself to a certain variety of tolerable, low-grade melancholia, and that's fine by me.
Most patients experienced tolerable neurotoxicity, mainly of grade 1 severity, with one grade 3 case observed at the third dose level.
Our toxicity results were also determined as tolerable with only one grade-3 toxicity (grade-3 GI) reported.
The 10 mg/m TP300 dose level was tolerable, but the frequency of grade 4 neutropenia during cycle 1 led to the recommended Phase II dose being 8 mg/m for cycle 1, increasing to 10 mg/m in subsequent cycles if tolerated.
Toxicity was tolerable, with a 7% grade III IV hematologic toxicity in the concomitant phase and 14% in the adjuvant phase.
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CEO of Professional Science Editing for Scientists @ prosciediting.com