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Although simulations have shown relatively minor excursions above tolerable concentrations in patients with moderate RI, and the two patients in this study with moderate RI who were administered 10 µg exenatide tolerated it well, therapeutic escalation from 5 to 10 µg bid by patients with moderate RI should be done conservatively.
Based on the Boyle van't Hoff plot, the tolerable limits for cell volume excursion were therefore 45 140% of isotonic volume.
Tolerable, however, is a relative notion.
This temperature requirement is sufficiently flexible that small excursions (+/−1.5°C) around this target are tolerable.
NOISE LEVEL -- Tolerable.
It was tolerable.
Legoland had been tolerable.
It is not tolerable.
That much was tolerable.
Still, adequate is tolerable.
Saturday mornings, however, are tolerable.
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CEO of Professional Science Editing for Scientists @ prosciediting.com