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If a DLT was observed, three additional patients could be recruited to that dose level.
The treated volume is thus a volume enclosed by the isodose surface corresponding to that dose level.
However, if two patients experience a dose-limiting toxicity no further patients would be accrued to that dose level.
If DLT was observed in 1/3 patients treated at a given dose level, then a further three patients were added to that dose level.
If DLT was observed in one of three patients in a cohort, a further three patients were recruited to that dose level.
If any of the first three patients experienced dose-limiting toxicities (DLT) at a dose level, three additional patients were enrolled to that dose level.
Similar(50)
The individual's dose reading for the next monitoring period should be reviewed to confirm that dose levels have returned to the expected range.
Refinements to the bio-shield plug design were suggested to ensure that dose rates in the port cell were within the design value for maintenance access.
Patients receiving oral corticosteroids were required to be on a stable dose (≤10 mg/day for ≥4 weeks) at initiation and to maintain that dose until month 12.
It's important to remember that dose, duration and age at exposure all play a role, but there is mounting evidence that these chemicals may be a factor in early puberty.
Evidence was insufficient to conclude that dose or mode of delivery influenced treatment outcome.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com