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This refined mechanism, exchanging single molecules within a macromolecular assembly, would enable isoform exchange without any necessity for demolition and reconstruction within the cell, and is expected to represent a principle, which may be exploited by other subcellular systems.
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Moreover, the concept of interplay between sequentially deployed core regulators is likely to represent a design principle widely applicable to the transcriptional control of mammalian development.
The proteins bearing the APD1 and APD2 domains show highly conserved N-termini but extremely polymorphic C-termini, with several distinct effector domains – thus, they appear to represent a mechanistic principle similar to the MAFB-N and Microscilla toxin N-terminal domains.
These dynamics are thought to arise from the system itself; indeed, the theory of self-organized criticality has been suggested to represent a universal organizing principle in biology [ 76].
As we pointed out in the introduction, debates concerning the moral acceptability of deception in medicine can be understood to represent a conflict between the principle of respect for autonomy and the principle of beneficence.
They seemed to represent a kind of culmination of the principle of survival of the fittest.
Localized network patterns are assumed to represent an optimal design principle in different biological networks.
We used the following principle to represent "is-a-kind-of" relations between concepts: If a concept A belongs to the concept class B, then the icon for B should be visible in the icon for A. For example, heart failure belongs to the class of cardiac diseases, and thus the icon for cardiac diseases should be visible in the icon for heart failure.
The principle of maxima for the variation of the entropy due to irreversibility represents a general principle of investigation for the stability of open systems, by which it is possible to predict some macroscopic shapes, originated by the spatial organisation, in Nature, both in living and in non-living objects.
If the members feel he would be the best person to represent the principles, ideals and goals, well, it has to happen by July 1".
It may represent a new principle to degrade oxygenated fatty acid derivatives formed by lipoxygenases or chemical oxidation initiated by reactive oxygen species.
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