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All cases accrued in this study had local pelvic relapse and the median time to progression after primary treatment was 16 months (9 120) in the 13 cases that had complete response, whereas the time to progression for the persistent or progressive disease cases was 4 months (range 2 7 months).
The median time to progression for all patients was 3.7 months.
The median time to progression for the study group was 20.47 weeks (range, 8 46 weeks).
New recommendations for trial outcome measures include the time to event end point of symptomatic skeletal events, as well as time to first metastasis and time to progression for trials in the nonmetastatic CRPC state.
Time to progression for all 31 patients calculated from the start of second-line therapy was 3.40 months (95% CI, 2.73 4.07).
Figure 1 shows the time to progression for each patient.
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The oral multi-kinase inhibitor, Sorafenib, has shown significant efficacy in prolonging the Time-to-Progression for tumours in two large, Phase III trials and is the standard treatment for patients with advanced HCC [ 11, 12].
Median time to progression (TTP) for patients treated in first to fourth line was between 6.2 and 7.6 months.
Cox acknowledged that there were problems in getting young women to take up careers in science and engineering, and said there were "big problems" that needed to be addressed when it came to career progression for women.
Examples include Aiolos (Ikzf3), Gata3 [281], [281], and others that have clear patterns of upregulation during DN1 to DN3 progression (for the complete list see [276]).
Median time to PSA progression (for non-responders) was 14.2 weeks.
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