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To further optimise Leishmania CRK3 potency, we synthesised an array of analogues by modifying the phenyl ring (Scheme 3).
To further optimise the 2A coexpression system, we used T2A and shorter versions of F2A inserted between GFP and CherryFP fluorescent "reporter" proteins.
To further optimise this process we induced mineralisation in the chondrogenic constructs before implantation by changing to osteogenic medium during the last 7 days of culture.
To further optimise the clarity and relevance of the questionnaire content, a number of items were modified following the first and second set of cognitive interviews.
To further optimise the intervention it was piloted with 12 patients (6 in NE Scotland and 6 in Glasgow) to determine its feasibility and explore qualitatively the potential for benefit.
The company will use the influx of data to further optimise its taxi delivery supply chain, powered by an Oracle ERP and Siebel CRM system.
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By simultaneous assessment of service provision and health-economic data health services research can contribute to further optimising emergency services.
8 12 The 'always event' (AE) concept (originally developed by the US-based Picker Institute 13) offers a person-centred approach to quality improvement (QI) that may further optimise different aspects of the patient's experience of their healthcare, and which can potentially be used routinely within many care settings.
20 Owing to the trial protocol and time and research funding limitations, we did not further optimise the intervention or implementation strategies other than to inform PNs after 3-month follow-up to use the criteria DFT >4 and DS >3 less rigidly.
Further studies are warranted to test if the association of CD8, Foxp3 and T-bet labelling will further optimise the prognostic prediction in patients treated with trastuzumab plus taxanes.
The response of neuroblastoma cells to R116010 was consistent with inhibition of CYP26, indicating that inhibition of RA metabolism may further optimise retinoid treatment in neuroblastoma.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com