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This disordered half of the chaperone may facilitate fast turnover between itself and its binding substrate, AscF, with the presence of AscF, in turn, able to induce the chaperone to become ordered.
Genomes have likely evolved to become ordered by replication timing on many occasions, some ancient.
Thus, reduction of the cofactor causes the isoalloxazine to move IN and the "melting helix" to become ordered.
This unstructured portion is mostly in the C-terminus and not expected to become ordered in the complex (see point 4 below).
Recently, it was suggested that intrinsically disordered proteins are able to become ordered following binding to their partner(s) and that this 'restores' the primacy of the classical structure-function paradigm according to which protein function is equated with a well-defined 3D structure [ 109].
Similar(55)
TM2 and its linkers to TM1 and TM3 become ordered, and so do the cytoplasmic half of TM6 and part of the linker between TM6 and TM7.
They exhibit considerable conformational flexibility and became ordered to form a "closed" conformation by interacting with the substrate.
Their suggestions become orders.
My suggestions become orders.
Chaos would become order.
I expect caution to become the order of the day".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com